`set -g mouse on` should be all that's necessary to enable mouse-wheel scrolling for tmux version 2.1 and up. This works for me.

https://superuser.com/questions/209437/how-do-i-scroll-in-tm...

Wow, thanks! I've been using tmux for about a month now to connect to my server, and I never knew this was possible.

Just to add a note that I updated recently and the mousewheel scrolling behaviour stopped and sent up/down terminal history commands instead. If this happens, there is a thread on the tmux github issues with some workarounds.

I’m pretty new to using tmux as more than a basic screen replacement, but it seems flexible enough that almost anything you want can be configured.